Gate News bot, Sky (formerly MakerDAO) founder Rune Christensen and Ethena founder Guy Young recently joined The Big Brain Podcast to explore topics such as how the DeFi ecosystem is maturing, why centralized trade-offs are no longer taboo, and how AI agents and protocol generalization are changing the future of finance. Rune argues that the era of DeFi's ideological frenzy is gone. DeFi, once driven by a lofty vision and decentralization supremacism, has now evolved into a solid, value-based industry, "In the past, you would raise a lot of money with high subscription rights and then cause the market to crash, now the key is: If you want to change the world of tomorrow, can you run a sustainable business today?" Real-world assets, once ridiculed, are now key to achieving this goal. Both founders agree that the future of DeFi will no longer be dominated by human users, but by AI agents. Rune envisions a shift to "hyper-rational, capital-focused" where intelligent agents will optimize across protocols at machine speed.